Blade Trinity (2005, Wesley Snipes, Kris Kristofferson, Jessica Biel)
A new challenge faces the preternaturally sharp hunter, Blade (Wesley Snipes), when a group of vamps resurrect the long-slumbering "Drake" (Dominic Purcell)--the ancient and all-powerful Count Dracula--and Blade meets the ultimate opponent. Teaming up with the Nightstalkers, a group of similar-minded hunters led by tough slayer-hottie Abigail (Jessica Biel) and her joke-a-minute partner Hannibal (Ryan Reynolds), Blade is ready for battle. However, Drake's handlers are an unruly bunch themselves, with sassy goth wench Danica (Parker Posey in a wonderfully exaggerated performance) doing her best to make things as unpleasant as possible. What's more, while Danica's vamp team is harvesting homeless people for their blood, the Nightstalkers' scientist creates a potion that can not only kill Drake but can take the entire bloodsucking race with him.